Synaptonemal Complex Components Promote Centromere Pairing in Pre-meiotic Germ Cells
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منابع مشابه
Synaptonemal Complex Components Promote Centromere Pairing in Pre-meiotic Germ Cells
Mitosis and meiosis are two distinct cell division programs. During mitosis, sister chromatids separate, whereas during the first meiotic division, homologous chromosomes pair and then segregate from each other. In most organisms, germ cells do both programs sequentially, as they first amplify through mitosis, before switching to meiosis to produce haploid gametes. Here, we show that autosomal ...
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Recent studies in simple model organisms have shown that centromere pairing is important for ensuring high-fidelity meiotic chromosome segregation. However, this process and the mechanisms regulating it in higher eukaryotes are unknown. Here we present the first detailed study of meiotic centromere pairing in mouse spermatogenesis and link it with key events of the G2/metaphase I transition. In...
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Pairing of homologous chromosomes in meiosis is critical for their segregation to daughter cells. In most eukaryotes, clustering of telomeres precedes and facilitates chromosome pairing. In several species, centromeres also form pairwise associations, known as coupling, before the onset of pairing. We found that, in maize (Zea mays), centromere association begins at the leptotene stage and occu...
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The synaptonemal complex proteins SCP3 and SCP1 are components of the synaptonemal complex, a meiosis-specific protein structure essential for synapsis of homologous chromosomes. Using polyclonal antibodies raised against SCPs of rat testis, we have studied the expression of these proteins in embryonic germ cells of the mouse embryo using immunohistochemistry and immunoblotting. This investigat...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2013
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1004012